Tab Groups is pretty much just unusable in High Contrast mode. See attached screenshot, where Firefox is running in High Contrast white-on-black mode. Each group has its colors inverted to what they should be - make it unusable for some people.

Panorama has been removed from Firefox 45, currently in Beta and scheduled for release on March 7th. As such, I'm closing all existing Panorama bugs. If you are still using Panorama, you will see a deprecation message in Firefox 44, and when 45 is released your tab group data will be migrated to bookmarks, with a folder for each group. There are also a few addons offering similar functionality. See https://support.mozilla.org/en-US/kb/tab-groups-removal for more info. We're removing Panorama because it has extremely low usage (about 0.01% of users), and has a large number of bugs and usability issues. The cost of fixing all those issues is far too high to justify, and so we'll instead be focusing our time and energy on improving other parts of Firefox.