Mousewheel scrolling is not working on my Windows 10 22H2, latest nighty and beta are affected. Stable still works.
I can click and drag the scrollbar, or I can middle click and move the mouse to scroll. But turning the wheel does nothing.

Regression window: https://hg.mozilla.org/integration/autoland/pushloghtml?fromchange=a8858873d38b456a3d1bd82f7737edc1fa4296b9&tochange=3525211fa094b4b009f13ff44e654b95822accf0

Seems a variant of bug 1630860 or bug 1798014.

security.sandbox.gpu.level = 0 avoids the problem.
gfx.webrender.software = true avoids the problem.
gfx.webrender.compositor = false does not avoid the problem.

I'm attaching my graphics info.

:cmartin, can you take a look?

From bug 1798014 comment 49

Does anyone experiencing this use a utility called "X-Mouse Button Control", or some similar mouse remapping software?

I have that. Checking its "Disable Scroll Window under Cursor" option avoids the problem.

Should this bug be closed, or do you want to add some workaround to avoid conflicts with that program?

Thanks for filing the bug! Sorry that you have ran into that "X-Mouse Button Control" scrolling bug, but unfortunately there is no simple way to work around it on our end without compromising security on your Firefox installation. (XMBC is such a low-level tool that it's very difficult for Firefox to tell that it's messing with us)

The author has been made aware of the XMBC bug and has a fix for it in the latest Beta. Hopefully when that goes live, everyone using XMBC won't have to deal with this issue.

BTW, "fixed" is misleading. Bug 1798014 only added a message in about:support, that's not really a fix. I filed this duplicate because that bug was marked as fixed so I thought I encountered a different problem.